Some Coptic families then approached the Anglican missionary Llwellyn Gwynne (who later became Bishop of Khartoum) for help and the Coptic Girls School was opened in 1902 but changed its name to the Church Missionary Society Khartoum Girls School in 1903.

[1] In 1948 Margo Iskinazi, a Jewish girl who was a student, at the Unity High, noted that there were Egyptian Copts, Sudanese Muslims, Greek Orthodox and Armenian Christians among her classmates.

[5] On 25 November 2007 the school came to international attention when one of its teachers was arrested by Sudanese authorities for allegedly insulting Islam by allowing the children in her class to name a teddy bear "Muhammad".

[10][11] Another Unity High School graduate, Takwi Sirskisian, was the first female Sudanese journalist[10] and published a monthly magazine for women called "Bint Alwady" (The Valley Daughter).

Meena Alexander, an internationally acclaimed poet, scholar, and writer, graduated from the Unity High School in 1964.