The trust runs Derriford Hospital, the Royal Eye Infirmary since 2013, and Plymouth's Child Development Centre.

In October 2018, the trust decided to move all its non-urgent orthopaedic surgery, about 200 cases a month, to the nearby Peninsula Treatment Centre, which is run by Care UK, in order to free up space at Derriford Hospital during the winter.

[5] The trust does not have an alongside midwifery led unit as recommended by the National Institute for Health and Care Excellence.

[9] The Northern, Eastern and Western Devon Clinical Commissioning Group gave the trust a £2.4 million advance payment in November 2015 to help its cash balance.

[11] According to the British Orthopaedic Association, the Peninsula Trauma Centre at Derriford was the best in the country in 2016 for treating open fractures.