On June 19, 1999, Texas Senate Bill 1288, authored by Judith Zaffirini and sponsored by Henry Cuellar, was passed during the 76th Texas Legislature which established the University of Texas(UT) Health San Antonio Laredo Regional Campus from the existing Mid Rio Grande Border Area Health Education Center(MRGB-AHEC).

[10][11] The bill would not take effect until September 1, 2021, and on November 30, 2021, a ceremony was held on campus to commemorate the center's creation.

The library of UT Center at Laredo, found on the first floor of the Academic Building, contains physical books that pertain to the various subject areas instructed and digital access to other UT System digital libraries for enrolled students.

This clinic provides the Laredo region with local access to neurology services, neuropsychology/diagnostic testing, genetic counseling, genetic testing, online support groups, support resources, and advanced treatment with clinical trials.

Similarly, the UT Center at Laredo employs a simplified logo to maintain their identity and message across their social media accounts.

The UT Center at Laredo's alternate logo depicts hierarchy, in a literal and visual sense, by including the Seal of the University of Texas System above the text: "The University of Texas Education & Research Center at Laredo."