The PlayStation 3, Wii and Xbox 360 versions of the game follow the film's plot more tightly, spanning eleven levels, with some liberties taken.

The PlayStation 3, Wii and Xbox 360 versions of the game are fast-paced platformers with some puzzle scenarios and plays similar to LEGO Indiana Jones: The Original Adventures, but can be finished in about an hour or two.

These versions also have the fewest bosses, which are simply a giant anaconda, a crocodile, and The Spirit of Adventure, Muntz's airship.

There are two biplane sequences, one at the start of the game that takes place immediately before a final battle over Paradise Falls, and another for the actual battle, and in both of them, a second player can "man the guns" and fire at incoming enemies and ground artillery with an on-screen reticule, while sharing the first player's camera view.

These versions also exclusively feature side areas that cannot be accessed the first time around without acquiring a certain tool, as well as fast-moving linear levels (namely on-rails chase sequences played from a reverse angle or river canoeing courses), where players cannot backtrack and must carefully avoid accidents that instantly require a restart from a checkpoint.

However, levels that are divided into multiple sections offer a fresh spring in between areas that can fully replenish health and a checkpoint is available at the start of each boss battle.

In between levels, players are taken to a campsite where they can purchase health upgrades and consumable supplies for power-ups, examine acquired tools, save progress and more.