She is the first Canadian to essay a permanent role on prime time Indian television, in Star Plus' top rated soap opera Saath Nibhaana Saathiya.
After graduating with honours, Uppekha was hired as an Associate Brand Manager at Cadbury Adams, where she worked for just over a year before quitting her promising corporate career to pursue her passion for the arts.
[citation needed] While navigating her way across unknown plains in Mumbai, Uppekha was lucky to bag her very first commercial/ad opposite Bollywood superstar Shah Rukh Khan.
There after came a slew of ads for various brands and with various Bollywood stars, including Hoppits with Priyanka Chopra, Yardley and Line App with Katrina Kaif, Just Dance with Hrithik Roshan, Simply Learn with Irfan Khan and various others for household brands including Parle, Dove, Pantene, Maruti, Karbonn Mobile, Blackberry, Mumbai Midday, Koryo, and others.
[2] In 2016, Uppekha bagged the permanent cast role on Star Plus's long-running hit soap opera Saath Nibhana Saathiya.
Her conniving yet fashionable character of Monika Modi struck a chord with audiences, and the antagonistic mother-in-law and daughter-in-law "Jodi" with co-star Lovey Sasan became widely popular.