[5] The series starred Giaa Manek (later replaced by Devoleena Bhattacharjee), Rucha Hasabnis, Rupal Patel, Mohammad Nazim, Vishal Singh, Loveleen Kaur Sasan respectively.

[12][13] The second season of the series, Saath Nibhaana Saathiya 2, premiered on 19 October 2020 on Star Plus starring cameo celebrities Devoleena Bhattacharjee, Rupal Patel, Mohammad Nazim, as well as Sneha Jain and Harsh Nagar (later replaced by Gautam Singh Vig) as protagonists.

Initially, Gopi faces many hardships, as Kokila is strict, while Ahem rejects her because of her illiteracy.

Rashi, helped by her mother Urmila, actively plots against her cousin, to sabotage her success.

With time, Kokila grows closer to Gopi, but doesn't support her choice of getting an education.

Kokila learns that Meera is alive and was ill-treated by Radha and made to grow up as an orphan in a temple.

Kokila regains her memory and the whole family is reunited after Radha's crimes are revealed, and she is imprisoned along with Tripti for trying to kill her and Meera.

Realizing that Radha will never reform, Gopi stabs her with a trishul repeatedly to save Rashi, killing her.

Kinjal separates from Dhaval and lives at Modi's house after an argument which causes Urmila's feigned memory loss.

Gaura, who seeks vengeance on Kokila for her brother's death, secretly has Meera marry her son, Dharam.

Madhu returns with her adopted daughter, Sona, seeking revenge against the Modis for Radha's death.

Paridhi has expelled Sahir and Sona from the Modi mansion and had Samar marry a rich woman, Monica.

In May 2012, lead Giaa Manek signed on to appear on the reality show Jhalak Dikhhla Jaa on rival network Colors TV.

[16] Saathiya producers objected, noting that Manek was under contract with their network and that doing a reality series could tarnish her onscreen image as a soft-spoken character.

[17] In January 2014, Rucha Hasabnis playing Rashi confirmed that she planned to quit the series any time in that year.

[21] In May 2016, Mohammed Nazim as Ahem quit the show because of one member of the production crew stating:[22] "Since the existing key actors aired their reservations about playing grandparents, the creatives had no option but to put the time leap on hold.

After brainstorming, the best idea seemed to bump off Ahem's character, so a new man could be introduced in protagonist Gopi's life to take the story forward,"Khalid Siddiqui was cast opposite Bhattacharjee as Krishna in May 2016.

[23] As their story decreased in ratings, in July 2016, Nazim was made to re-enter the series as Jaggi, a look-a-like of Ahem's illegitimate twin half-brother.

The outside shell of the Modi Mansion shown in the episodes was of the Shubham Villa located on Madh Island.

[28][29] Earlier, the United States was considered, but was cancelled and replaced with Singapore due to the studio's budget.

[30] On 26 May 2021, Shoonya Square Productions announced a reboot of Saathiya on Star Plus's Sister channel Star Bharat with similar cast figures including Giaa Manek, Mohammad Nazim, Rupal Patel and Vandana Vithlani reprising their roles.

[37][38][39] It was dubbed in Indonesian and aired under the title Gopi (according to the main character) starting 15 September 2016 until 19 April 2017.

[45][46][47] Saath Nibhaana Saathiya aired in Pakistan on Urdu 1 and H Now Entertainment but was later discontinued due to the censorship of Indian content.

[52] With a low number of viewers in May 2010, the series' attention increased gradually and eventually became one of the top Hindi television shows at that time.

[60] In December, the series garnered its highest rating of 7.58 TVR, being the most watched Hindi GEC in that week for that specific timeslot.

[80] In 2015, it maintained its weekly position in top ten watched Hindi GEC ranging between 3.5 and 4 TVR.

[90] The clip from an episode where the lead character Gopi (Giaa Manek) washes a laptop went viral and was subjected to various trolls and criticism.

[91] On 21 August 2020, music composer Yashraj Mukhate uploaded an edited video which featured the characters Kokila (Rupal Patel), Rashi (Rucha Hasabnis) and Gopi (Gia Manek).

It was recorded in the soap opera accompanied by a rap song by Rupal Patel in which Kokila scolds Rashi for putting up the cooker without the chana (known also as gram or chickpeas) in the kitchen.

[92] The video quickly garnered over 4.5 million views as on 24 August 2020 in Instagram and memes also trended related to the rap song.