Upperman was listed as one of the United States' best high schools by U.S. News & World Report in 2008.

[2] On August 22, 1959, Upperman High School opened with an enrollment of 363 students from grades 9 through 12 on the campus of the former Baxter Seminary.

In 1976, a new school building was built on the same campus and enrollment was expanded to include grades 7 through 12.

[4] Upperman's Lady Bees 2012 softball team finished third in the programs first ever appearance in the Class AA State Tournament.

Other groups include the Academic Team, the Student Government, and a Color Guard and Marching Band known as the Regiment of Black.