Uppland Runic Inscription 53 is a runestone built into a wall in Gamla stan, the old town in central Stockholm, Sweden.

Preserved written records from the old town give no hints of a developed knowledge in writing and reading runes in Stockholm.

ᚦᚬᚱ[..]ᛅᛁᚾþor--ain᛫*ᛅᚢᚴauk᛫*ᚠᚱᛅᚤᚴᚢᚾfraykun᛫'ᚦᛅᚢ[...]þau...-᛫*ᛋᛏᛅᛁᚾstain᛫'ᛁᚠᛏᛁᛦiftiʀ[...]-...ᛋᚢᚾsunᛋᛁᚾsin [1]ᚦᚬᚱ[..]ᛅᛁᚾ ᛫ ᛅᚢᚴ ᛫ ᚠᚱᛅᚤᚴᚢᚾ ᛫ ᚦᛅᚢ[...] ᛫ ᛋᛏᛅᛁᚾ ᛫ ᛁᚠᛏᛁᛦ [...] ᛋᚢᚾ ᛋᛁᚾþor--ain * auk * fraykun ' þau...- * stain ' iftiʀ -... sun sinWhile the stone is not signed and its style can not be associated with any known runemaster, it is typical for stones carved in Uppland, north of Stockholm, during the later part of the 11th century.

The result showed the ornaments of the stone were most likely cut by an experienced master (deep grooves, regular stroke pattern) and a less proficient apprentice (more shallow grooves, irregular strokes), while the cross shape might very well have been added after the stone was erected (when the weight of the mason tools quickly makes the cutting awkward).

A second runestone found in the old town, U 274, originally located in a wall by the southern city gate near Slussen, is today kept in the Museum of Medieval Stockholm.