In 1965 Glenbard East left to join the Des Plaines Valley League and was replaced by St. Charles High School.

Naperville Community and Wheaton Central left in 1975 to join the newly formed DuPage Valley Conference.

South Elgin High School joined upon opening in 2005, preemptively taking DeKalb's place, as they left in 2006.

Starting in the 2018–2019 school year, St. Charles North, St. Charles East, Batavia, and Geneva will leave for the newly formed DuKane Conference along with Wheaton North, Wheaton Warrenville South, Glenbard North, and Lake Park from the DuPage Valley Conference while new member, Glenbard South High School joins in and the River and Valley Divisions became eliminated.

Young men and women may compete in basketball, bowling, Dance, cheerleading, cross country, chess, esports, golf, gymnastics, soccer, swimming & diving, tennis, track & field, speech, and volleyball.