Starting in 1800 she made three voyages from Liverpool as a slave ship in the triangular trade in enslaved people.

1st voyage transporting enslaved people (1800–1801): Captain David Williams sailed from Liverpool on 30 December 1800.

[3] Urania acquired captives at New Calabar and arrived at St Vincent on 29 July 1801.

[2] 2nd voyage transporting enslaved people (1802): Captain John Preston sailed from Liverpool on 12 February 1802.

Phillips and his chief mate were killed, and Urania had suffered so much damage it was feared that she would be condemned.

[5] The Essequebo and Demerary Gazette of 24 November 1804 reported that "on Wednesday the 28th Instant, at the Store of Robert Younghusband Esqr.

A small Cargo of Healthy Young Angola Slaves; Imported in the Ship Urania, Capt.