Urban Strike takes place in 2001 (2006 in SNES/Game Gear/Game Boy release) and centers around the antagonist H. R. Malone, a millionaire media mogul who once ran for President of the United States.

The first mission takes place in Hawaii, where the player character intercepts Malone's attempted theft of giant mirrors and sees to the rescue of a plastic surgeon being targeted by assassins.

After the mission's completion, the plastic surgeon reveals that he had operated on a horribly deformed burn victim in Washington DC many years ago, who later turned out to be Malone.

The plastic surgeon says he was marked for death because he had recently deduced that the man he actually operated on was Carlos Ortega, who was one of the two main antagonists in (and was presumed killed at the end of) Jungle Strike.

Urban Strike is a helicopter based shoot 'em up, mixing action and strategy, retaining its predecessor's core mechanics, and expanding on the model with additional vehicles and settings.

This time, the campaign takes the player all over the North American continent, beginning in Hawaii and moving through locations in Mexico, San Francisco, New York, and Las Vegas.

A new feature introduced in this game is on-foot missions, where the player is required to leave the helicopter at certain points and enter internal environments armed with a rifle and missile launcher.

[27] Reviewing the Genesis version, GamePro deemed it "a top-notch helicopter-combat cart", citing the "ten massive missions", combination of airborne and ground-based combat, new helicopter moves and techno soundtrack.