Uriel Holmes (August 26, 1764 – May 18, 1827) was a United States representative from Connecticut.
He attended the common schools and graduated from Yale College in 1784.
Later, he studied law and was admitted to the bar in 1798 and commenced practice in Litchfield, Connecticut.
Holmes was elected as a Federalist to the Fifteenth Congress and served from March 4, 1817, until his resignation in 1818.
He died in Canton, Connecticut, in 1827 and was buried in East Cemetery in Litchfield.