[2] The endocrine heart is composed of specific myoendocrine cells that synthesize and secrete the natriuretic peptide hormones, which exhibit diuretic and vasorelaxant properties; secretion is the basis for a paracrine system regulating water and sodium reabsorption.

[4] When administered intravenously, urodilatin induces strong diuresis and natriuresis with tolerable hemodynamic side effects.

[5] Urodilatin is localized in the kidney, differentially processed (involved in the regulation of body fluid volume and water-electrolyte excretion, while circulating), and secreted into the urine.

[3] A message for the preprohormone is transcribed in the heart and kidneys from the gene of NP type A, resulting in a cGMP-dependent signal transduction, which induces diuresis and natriuresis,[6] differentially processed to a peptide of 32 amino acids from the same precursor as renal ANP, may not be identical to the circulating cardiac hormone ANP.

Urodilatin renal natriuretic peptide potency equals or exceeds that of Atriopeptin [ANP-(99-126)], the prototype of cardiodilatin.