[3] The founding of a Bible college in the St. Louis area was initiated by Harry Branding (superintendent of the Missouri District for the UPCI), who formed a committee to look into this possibility, this committee presented the idea to the Missouri District Board.

On September 13, 1968, Gateway College officially opened at 3155 Charbonier Road in Florissant, Missouri.

After four decades, President Darrel Johns led the school through a transition to UPCI ownership.

[1] The student body is 41% Male and 59% Female; 82% are full-time and 18% are part-time; 69% are at least partly on campus while 31% are fully distance learners; 72% are white or Caucasian, 14% are Hispanic, 4% are Black or African-American, 4% are two or more races, 1% are Asian, 1% are American Indian or Alaskan Native, and 2% are unreported.

[12] The campus, formerly a CenturyLink office complex, consists of five buildings sitting on 43 acres of land.