Relations between the United States and the Uruguay traditionally have been positive, based on a common outlook and emphasis on democratic ideals.

In historical perspective, starting in the 1890s Uruguay took the lead in reaching out to the U.S. in order to counter the heavy British business presence.

In 2002, The United States and Uruguay created a Joint Commission on Trade and Investment (JCTI) to exchange ideas on a variety of economic topics.

This exemption was withdrawn on April 16, 2003, based on the high overstay rates for Uruguayans and worldwide national security concerns.

[2] Nevertheless, Vázquez sought the help of President George W Bush in the face of the crisis with Argentina around the Uruguay River pulp mill dispute.