Both countries were founding members of the Mercosur, and both are full members of the Rio Group, the Latin Union, the Association of Spanish Language Academies, the Organization of American States, the Organization of Ibero-American States, the Union of South American Nations, the URUPABOL, the Cairns Group and the Group of 77.

[3] José Gervasio Artigas, the most celebrated historical figure in Uruguay, spent his last 30 life years exiled in Paraguay.

[5][6] The 2011 Uruguayan census revealed 1,781 people who declared Paraguay as their country of birth.

[8] As of 2007, there were over 1,000 Uruguayans living on Paraguayan territory,[9] a figure that notably increased a decade later.

[11] Uruguayan residents in Paraguay have their own institutions, for instance, the Consultative Council "José Gervasio Artigas" in Asunción.