SR-22 begins in Antimony as a continuation of John's Valley Road and heads generally north through a canyon to Otter Creek Reservoir and Otter Creek State Park, where it ends at an intersection with SR-62.

[1] The road from Widtsoe north to Antimony became a state highway in 1914, and in 1915 it was extended west to SR-11 (by 1926 US-89) in Junction.

[3] To improve route continuity on a shortcut between California and Colorado that included the portion of SR-22 between US-89 and SR-62 at Otter Creek Junction, that part was transferred to SR-62 in 1967.

(With the completion of I-70 through the San Rafael Swell in 1970, this is no longer a popular route.)

The legislature removed John's Valley Road from the state highway system in 1969, turning SR-22 into a short spur from SR-62 to the bridge over Antimony Creek just south of Antimony.