It provides several transport connections for commuters with many London Underground stations situated either on it or within walking distance.

In 1972, the thirty-third episode of Monty Python's Flying Circus featured a sketch about a team of mountaineers "climbing" the Uxbridge Road.

Emerging from a roundabout in Shepherd's Bush, the Uxbridge Road enters several important places in west London.

The Shepherds Bush/White City area is now the site of the new Westfield London retail development, which opened in October 2008.

Notable buildings on this stretch of Uxbridge Road include St Stephen's Church, the Bush Theatre,[1] and the Princess Victoria public house.

Acton is primarily a residential district, though there is a long stretch of shops (including a large Morrisons, pubs, and restaurants, mostly concentrated on the Uxbridge Road.

Ealing Broadway is the main retail centre that is directly served by the Uxbridge Road.

This is another very congested part of the road (like Ealing Broadway), because it is very popular as a shopping area for the public and tourists.

Hayes is home to a few industrial sites, unlike most of the other areas Uxbridge Road passes through.

West Ealing, Hanwell and Southall railway stations are themselves within walking distance of Uxbridge Road.