It originates in the Zhytomyr Oblast (province) of northern Ukraine, and then flows briefly near the delta of the Berezina River.

The Uzh then flows near the city of Chernobyl of Kyiv Oblast, before emptying into the Pripyat River.

The width of the valley varies from 1 to 7 km, and the river itself ranges from 5 to 40 meters.

The mineralization of the river's with the following average measurements: The river takes its source from the spring thaws and it freezes over in the winter, only thawing in late March, from which it takes much of its water supply.

The cities of Korosten and Chernobyl are located on the Uzh river.