The university has 20 faculties (biological, geographical, engineering, history and international relations, mathematical, medical, medical No.2, dental, economic, health and physical education, information technology, postgraduate education and pre-University training, social sciences, foreign philology, tourism and international communications, physical, philological, international economic relations, chemical, legal), 2 educational and scientific institutes, 115 departments, territorially separated structural subdivision ‘Branch of SHEI’ UzhNU ‘in Lviv, natural sciences and humanities college.

Among the higher education institutions in Ukraine in terms of the number of teachers with scientific degrees UzhNU − in 5th place.

Uzhhorod National University is the first higher educational institution in the history of Zakarpattia, which has passed a long and thorny path of its formation, and its prehistory dates back several centuries.

College of Jesuit Fathers (1613−1773) The chronology of the origin of higher education in Zakarpattia can be traced back to 1613, when the county prefect of Ung and Zemplin count Georgy Druget on November 23, 1613, allowed to establish a monastery of the Jesuit order and a collegium (college / higher gymnasium) in Humenno (now Slovakia).

Uzhhorod National University and other educational institutions of Ukraine started the international exchange of students and teachers within the Erasmus + program in 2014.

Every year UzhNU students have internships abroad − in Slovakia, Germany, Turkey, participate in international schools, training, have the opportunity to become scholarship holders and win grant programs of academic exchanges named after Fulbright (USA), The scholarship program for graduates from Ukraine by the European-University in Frankfurt (Germany), Summer International School in Vilnius (Lithuania) and others.

Maldives, Zimbabwe, Austria, Czech Republic, Slovakia, Romania, Hungary, Turkey, USA, Netherlands, and other countries.

The scientific base consists of research institutes, laboratories, and centers, notably the Research Institute of Solid State Physics and Chemistry, Phytotherapy, Carpathian Studies, Central Europe, and Ukrainian Studies named after prof. Molnar, Means of Analytical Technology, Political Regionalism, Brain, Trauma, Family Medicine.

Based on the concluded agreements, international cooperation with 86 scientific institutions in Slovakia, Hungary, Romania, Poland, the Czech Republic, Croatia, France, Germany, Russia, the US, Italy, Lithuania, Turkey is carried out.

Extensive international cooperation of the university contributes to the expansion of scientific research in various fields of knowledge: physics, chemistry, biology, medicine, philology, archeology, problems of the Carpathian region, etc.

In recent years, young scientists have repeatedly won grants from the President of Ukraine and scholarships of the Cabinet of Ministers of Ukraine for young scientists, participated in international (e.g., Germany, Japan, USA, Slovakia, Hungary, and other countries) and national conferences.

Uzhhorod National University is one of the largest patent holders for protecting original technical solutions among higher education institutions in Ukraine.

In particular, the university's research and teaching staff became the authors of patents of Ukraine for invention − 409, utility model − 526, and industrial design 1.

Archaeologists of Uzhhorod National University were the discoverers of the parking lot of primitive man of the Paleolithic era near the village of Korolevo, which is a monument of European importance.

The Laboratory of Space Research - one of the three stations for optical observations of artificial satellites of the Earth - houses the tallest telescope in Ukraine.