She appeared in Une lâche (1907) with Albert Dieudonné,[3] Le Grand Soir (1908),[4][5] The Children's Cardinal, L'Aiglon,[6] and Racine's Phedre.

[7] Critic André Germain counted her as one of the "three best actresses in Paris" in 1921, alongside Berthe Bady and Ève Francis.

[8] Sergine appeared in several silent films, including Mary Stuart (1908), The Great Breach (1909), Pygmalion (1910), L'écharpe (1911), Moderne Galathée (1911), Les deux gosses (1912, 1916), Pro Patria (1914), Le médecin des enfants (1916), and Le geste (1917).

[9] During World War I, she traveled to a military hospital to tell the wounded Jean Renoir of his mother Aline Charigot's death, and caused an uproar with her short dress and cropped hair.

[10] In 1916, she recited Saint-Georges de Bouhélier's Ode to Our Friends in the United States, at an event in the Sorbonne.