Muraleedharan was born to Vannathanveetil Gopalan and Nampally Vellamvelly Devaki Amma on 12 December 1958 at Eranholi, Thalassery in Kannur District.

[5] Muraleedharan began his political activities during the days of National Emergency that gripped India from June 1975 to March 1977.

[9] Muraleedharan left for Mumbai when he was appointed All India General Secretary of ABVP for the term 1994–1996.

[10] Muraleedharan returned to Kerala in 1997 on a research project of Khadi and Village Industries Commission at Trivandrum.

He was deputed to assist Venkaiah Naidu at the BJP Central Election Control Room at New Delhi.

[13] In 1999, Muraleedharan was appointed Vice Chairman of Nehru Yuva Kendra under Department of Youth Affairs and Sports, Government of India.

[15] During his tenure as the BJP Kerala Vice president (2006–2010), his major assignments were to provide ideological orientation to the party workers in Kerala as part of training cell activities and impart and oversee training to the local body members of the BJP.

[21] In the 2024 Indian general election, he contested for BJP from Attingal Lok Sabha constituency,[22] but ended up in third place.