7425381677ENSG00000128564ENSMUSG00000037428O15240Q0VGU4NM_003378NM_001039385NP_003369NP_001034474VGF or VGF nerve growth factor inducible is a secreted protein and neuropeptide precursor that may play a role in regulating energy homeostasis, metabolism[5] and synaptic plasticity.

VGF gene encodes a precursor which is divided by proteolysis to polypeptides of different mass, which have a variety of functions, the best studied of which are the roles of TLQP-21 in the control of appetite and inflammation,[8][9][10][11][12][13][14][15] and TLQP-62 as well as AQEE-30 in regulating depression-like behaviors[16][17][18][19][20] and memory.

[21][22] The expression of VGF and VGF-derived peptides is detected in a subset of neurons in the central and peripheral nervous systems and specific populations of endocrine cells in the adenohypophysis, adrenal medulla, gastrointestinal tract, and pancreas.

[24] Physical exercise significantly increases VGF expression in mice hippocampal tissue and upregulates a neurotrophic signaling cascade thought to underlie the action of antidepressants.

[31] VGF expression has also been shown in damaged peripheral nerves, and it is thought to have a role in neuropathic pain.