[7][8] Ramsoomair said that he began the strip due to boredom at work; he created comics during his lunch breaks.

(His answer on the FAQ page said it was bad timing, probably in reference to the September 11 attacks that happened that same month.

[16] However, he later began to update the main Patreon account again on July 20, 2023,[17] and released a new addition to comic sometime in December of the same year.

"[20] Joystiq has defined them as "adorable characters who feel most at home with violence, language, and sexual innuendo".

[29] The alter ego of Scott Ramsoomair, Pantsman is an incompetent superhero who concealed his identity by wearing trousers and sometimes underpants on his head.

[31] Chris Boe, a friend and associate of Ramsoomair, created an animated adaptation of VG Cats.

[34] Bad Mushrooms, a sprite comic created by Ramsoomair prior to the creation of VG Cats, is hosted on VGCats.com.

Super Effective, also done by Ramsoomair, began in April 2008 as a comic parody of the popular game series Pokémon.

After comic #380 in 2018, Scott created a Patreon account for furry-themed pornography based around Leo and Aeris among other video game related characters titled VG Lewds.

[36] On the same day as the aforementioned comic, Scott stated in a blog post that the site's advertising revenue was no longer able to sustain him financially, and asked his users to help "support me in this newest venture".

[36] As of March 2022, the VG Lewds Patreon was shut down without comment, with Ramsoomair later stating that he wanted to focus on an ending for the strip.