Vaccine-naive

Vaccine-naive is a lack of immunity, or immunologic memory, to a disease because the person has not been vaccinated.

There are a variety of reasons why a person may not have received a vaccination, including contraindications due to preexisting medical conditions, lack of resources, previous vaccination failure, religious beliefs, personal beliefs, fear of side-effects, phobias to needles, lack of information, vaccine shortages, physician knowledge and beliefs, social pressure, and natural resistance.

[1][2][3][4] Communicable diseases, such as measles and influenza, are more readily spread in vaccine-naive populations, causing frequent outbreaks.

Vaccine-naive persons threaten what epidemiologists call herd immunity.

Fewer individuals available to transmit the disease reduce the incidence of it, creating herd immunity.

The time-course of an immune response begins with the initial pathogen encounter, (or initial vaccination) and leads to the formation and maintenance of active immunological memory.