Derbez participated in Univision's first reality dance competition, Mira Quien Baila (2010) and was the winner of the shows first season.

[8] He acted in the famous series Gossip Girl: Acapulco (2013) as Maximiliano 'Max' Zaga, one of the protagonists, alongside Alexis Ayala, José María Torre, and Issabela Camil.

In 2016, Vadhir played the role of César Suárez, the psychopathic son of a drug lord in the soap opera La querida del Centauro, a production of Sony Pictures, Teleset, and in collaboration with Telemundo, the show was aired in the United States, Mexico, and South America.

In the same year the actor played a lead role in the first series shared amongst TV Azteca and Televisa Blim, Entre correr y vivir, based on the lives of Ricardo and Pedro Rodríguez.

[9] Entering the international market, the actor obtained a role on the Netflix series, Sense8 (2016) alongside Miguel Ángel Silvestre and Alfonso Herrera.

[11] Afterwards he earned a lead part in the Broadway musical Rock of Ages (2014), playing the role of Jerry, along with the actress and singer Dulce Maria.