Vaksince (Macedonian: Ваксинце, Albanian: Vaksincë) is a village in the municipality of Lipkovo, North Macedonia.

When it fell apart at the beginning of the 20th century, Albania gained independence on November 28, 1912, during which the majority of citizens in and around Vaksince were in favor of their region belonging to this new state.

However, Serbia was able to persuade the great powers that most of the Albanian settlement areas in Macedonia came under its rule, including Vaksince.

Overall, several Albanian civilians, two NLA fighters and several Macedonian soldiers and police officers lost their lives in the clashes over Vaksince.

Vaksince, like other places in the region, was then closely monitored by the international missions of the OSCE, NATO and the EU.