The valley is drained by La Brancla, a tributary of the Inn basin, near Ramosch.
The valley belongs to the municipalities of Sent and Ramosch in the Swiss canton of Graubünden.
The main localities in Val Sinestra are Zuort and Vnà.
The Val Sinestra is connected to the Val Fenga by the 2,608 metre high pass named Cuolmen d'Fenga.
There is also a Hotel from 1912 in the valley, which used to serve as a Kurhaus (spa house).