Hessler planned to work in television, and in early 2006 she wanted to replace Alessia Marcuzzi to host Le Iene, but lost to Cristina Chiabotto.

In March 2006, she made her debut as a TV show host at the Festival di Sanremo with Claudia Cedro, Francesca Lancini, and Marta Cecchetto.

Hessler was the face of the DSL brand "Alice" (a service of Telefónica Europe) in both Germany and France until late October 2011.

She plays Greek princess, Irina, in the 2008 Asterix at the Olympic Games (French: Astérix aux Jeux Olympiques), a film that also stars Clovis Cornillac, Alain Delon, and Gérard Depardieu.

She also plays the leading female role in For A Night of Love (Italian: Per una notte d'amore), which was filmed in Italy and released in 2008 as a two-part TV special,[6] likewise in Cenerentola (2011) and One Thousand and One Nights: Aladdin and Sherazade (2012) (Italian: Le mille e una notte: Aladino e Sherazade).