[2][3] Born and raised in Thessaloniki, Greece, Pavlidis started his professional career with VfL Bochum in 2016 and then represented Willem II before signing with AZ Alkmaar in 2021, being crowned the Eredivisie top scorer in 2024.

[6][7] On 23 January, he scored his first goal with the club after Marios Vrousai's assist in a 3–2 away KNVB Beker win against FC Twente.

[10][11] Subsequently that year, on 2 August, in the opening game of the 2019–20 Eredivisie Pavlidis scored twice as Willem II won 3–1 against PEC Zwolle.

On the final matchday, Pavlidis scored a stunning solo goal in a 2–1 win against Fortuna Sittard, that kept Willem II in the Eredivisie.

He made his debut for AZ on 14 August as a substitute against RKC Waalwijk and started his first match four days later in a UEFA Europa League qualifier against Celtic.

[14] In the 2022–23 season, Pavlidis was sidelined for two months with an ankle injury, but still managed to score eight goals in the thirteen matches he played before the winter break.

[20] He made his competitive debut for his new club in a 2–0 loss to Famalicão on 11 August 2024,[21] and scored his first goal in a 3–0 win against Casa Pia three days later.

[23] On 11 January 2025, Pavlidis won his first trophy with Benfica, as they defeated crosstown rivals Sporting CP in the Taça da Liga final on penalties following a 1–1 draw in normal time.

[29] On 29 August 2019, Pavlidis was called up to the Greek senior team by coach John van 't Schip for the forthcoming Euro 2020 qualifiers against Finland and Liechtenstein.

In his celebration, he paid an emotional tribute to his recently deceased national teammate George Baldock, who had died the day prior.