Vapotherm Inc. is a publicly held corporation based in Exeter, New Hampshire that was founded in 1999 as a medical device manufacturer after creating the first heated and humidified high flow therapy nasal cannula system.

In 2009, Vapotherm released a new flagship product replacing the Vapotherm 2000i (that had been recalled in 2005, and then re-approved for use in the market in 2006); boasting a completely integrated electronic flow meter and electronic blender, as well as an internal oxygen analyzer.

In November 2015 Vapotherm announced its own model of medical air compressor, specifically to be used with their flagship Precision Flow device.

In 2005, contaminated Vapotherm 2000i respiratory gas humidification devices were associated with an outbreak of Ralstonia mannitolilytica bacteria in children in the United States.

[2] Vapotherm worked with the CDC and FDA to revise the operating manual and reduce risk to patients, and the 2000i was reintroduced on 1 February 2007.