Vasilissis Sofias Avenue

The part from Syntagma Square to the intersection with Alexandras Avenue was renamed after Queen Sophia, the consort of King Constantine I.

As many historical buildings and landmarks are located on the avenue, such as the Old Royal Palace (today housing the Greek Parliament) and the National Gardens of Athens, the mansions of very important Greeks and foreigners (today most of them housing embassies and museums) (e.g. the residence of the Greek Prime Minister Eleutherios Venizelos-now part of the British embassy, the mansion of Sophie de Marbois-Lebrun, Duchess of Plaisance-now the Byzantine and Christian Museum, the mansion of business magnate and tycoon Othon Stathatos-today part of the Goulandris Museum of Cycladic Art), Vasilissis Sofias Avenue is one of the most chic and prestigious streets in the Greek capital.

Except from residences, medical doctors' private practices, banks, museums, embassies and high-end hotels are common on this historical street.

The westbound lanes turn into Amalias Avenue and Panepistimiou Street, and the northbound of Amalias turns into Vasileias Sofias Avenue and Panepistimiou Street ; there is no traffic flow from the eastbound of Panepistimiou Street as it forms a one-way route westbound, and since the 2000s transit traffic has been excluded.

After World War II and the Greek Civil War, it added modern eight-to-ten storey buildings in most of the intersection (mainly to the north) with traffic and street lights installed.