It is located in Athens, Greece, on Vassilissis Sofias Avenue, within the Hilton Area, adjacent to the Kolonaki and Pangrati neighbourhoods.

It was designed by a team of architects including Emmanuel Vourekas, Prokopis Vasileiadis, Anthony Georgiades and Spyro Staikos.

[5] Guests at the hotel included Greek shipping magnate Aristotle Onassis, singer Frank Sinatra, director Ingmar Bergman and actor Anthony Quinn.

In more recent years, the hotel displayed artworks and invested regularly in lobby exhibitions of artists from Greece and abroad.

[5] In 2003, anticipating the 2004 Summer Olympic Games, the Hilton Athens was renovated by Greek architects Alexandros Tombazis and Charis Bougadelis.