[2] On 20 August 2015, Alexis Tsipras, who had been the prime minister of Greece since January 2015, resigned and asked for an interim government to be formed before an election could be held on 20 September.

[13] However, the Bristol Anglo-Hellenic Cultural Society has noted that her appointment did "not actually represent a real step forward in equal rights in Greece" due to it being a constitutional necessity.

[14] On the 66th anniversary of the National Day of the People's Republic of China, Thanou-Christophilou was among those in attendance at the Chinese embassy in Athens, as well as fellow former prime minister of Greece, Costas Simitis.

[16] On 18 March 2016, Giorgos Roupakias, who had been charged with the murder of Pavlos Fyssas in September 2013, was released from custody after completing the maximum of 18 months in pretrial detention.

Before his release, Thanou-Christophilou had criticised the Athens Bar Association (DSA) and Ministry of Justice, Transparency and Human Rights for failing to ensure the trial of Roupakias and other Golden Dawn members took place before the end of their pretrial detention period.

[17] In April 2016, Thanou-Christophilou announced that she would be stepping down from heading an investigation into a prosecutor's decision to shelf a probe into businessman Andreas Vgenopoulos and his dealings with the now defunct Laiki Bank.

She made the decision after the prosecutor in question, Georgia Tsatani, accused her of having too close ties to Dimitris Papangelopoulos, an Alternate Minister in the justice ministry.

Thanou-Christophilou said she was stepping down to "protect the standing and trust" of the judiciary and her role, and instead the investigation was to be headed by Aspasia Karellou, the deputy president of the Court of Cassation.

The action triggered disciplinary hearings against him, which, following an appeal against the initial decision for being "too mild", he was relinquished of his duties and barred from entering the next election for the head of the prosecutors' office in Athens.