[5] Following the dissolution of the Greek parliament in 1989, Skouris served as the Minister of the Interior briefly during the caretaker government.

[5] Since 10 May 2017, he has been the second chairman of the Adjudicatory Chamber of the FIFA Ethics Committee, succeeding the German Hans-Joachim Eckert.

President Skouris has presided over several landmark rulings since joining the court, including B.F. Cadman v. Health & Safety Executive (C-17/05), decided in 2006, which held that pay scales based on seniority were not gender discrimination, unless it could be proved otherwise that seniority was not the discriminatory factor.

[9][10] Other notable cases include Brian Francis Collins v. Secretary of State for Work and Pensions (C-138/02), decided in 2004, which struck down a discriminatory employment benefits law in the United Kingdom, allowing access to benefits for those of an EU nationality,[11] and Commission of the European Communities v. Federal Republic of Germany C-112/05 which struck down the "Volkswagen Law", against the wishes of the German government and labor unions.

As a significant result of the ECJ intervention, associative discrimination became a part of the UK Equality Act 2010.

The neutrality of President Skouris was questioned because of his acceptance of the Grand Collar of the Order of Makarios III of the Republic of Cyprus in 2006 and visits with the leadership of the southern portion of the island, where many refugees remain, months before the ruling.