A refugee from Akdağmadeni, he moved to Athens as a child and studied law.
[2] He fought in WWII, and became part of EAM during the occupation, becoming the director its press department after the liberation, for which he was imprisoned in 1947.
[1][2] Released in 1951, from 1952 to 1956, Ephremidis was chief editor and director of the leftist newspaper I Avgi.
He was elected to the Hellenic Parliament with EDA from his release until the outset of the military dictatorship, when he fled to Western Europe.
In 1982 he was elected vice chair of the Communist and Allies Group, and kept his office while the parliamentary group in 1989 was renamed to Left Unity and in 1995 merged to today's European United Left–Nordic Green Left (GUE/NGL).