Vaucluse is an unincorporated community in Aiken County in the U.S. state of South Carolina.

Employing 50 'operatives' on 1500 spindles and 25 looms, the mill was incorporated by local planter Christian Breithaupt in 1833, with later investors George McDuffie, John Bauskett, and William Gregg.

Gregg found it under-capitalized and too small for economic survival, producing an unmanageable variety of products, and suffering due to a lack of active management.

Gregg observed 'the most indifferent overseer's house in Lowell, Massachusetts, at least such as I saw, cost more than the whole village of Vaucluse, containing upwards of 200 inhabitants including a comfortable dwelling recently built as a residence for one of its owners'.

1880 employed 300 operators on 10,000 spindles under ownership of the Graniteville Company until its recent closure.