[6] After saving Earth in the previous game, Vectorman's spaceship is targeted and destroyed by a missile.

[7] A sequel was immediately greenlit, though the game would feature a rushed development cycle; the lifespan of the Sega Genesis was already coming to an end by the time of the late 1995 release of the original Vectorman, and despite continued good sales, new releases were becoming increasingly rare in 1996.

[2] Jon Holland also returned to compose the game's soundtrack, which ventured into a more varied electronic music sound.

[2] Prior to release, the Sega Channel service held a contest that allowed artists to submit drawing of their own ideas for Vectorman "morphs", with the winner having their work Judges then chose the best one to be transformed in Genesis art, as well as being put on the Sega Channel.

[13] While Vectorman 2 was generally praised as a game that pushed the limits of the Sega Genesis, and as one of the few games for the system was not a cheap licensed cash-in at the end of the platform's lifecycle, it was generally viewed less positively than its predecessor, and struggled to commercially compete with the Donkey Kong Country sequels in the same way.

Shawn Smith, Dan Hsu, and Crispin Boyer applauded its traditional side-scrolling gameplay, huge levels, graphics, and animation, especially on the bosses.

The reviewer said that compared to the first game, it "has cleaner graphics, more sound and voice effects, and faster, smoother gameplay.

[14] Multiple attempts at making a Vectorman 3 were made in the late 1990s and early 2000s, though all were cancelled by Sega prior to release.