Venafrum was an ancient town of Molise, Italy, close to the boundaries of both Latium adiectum and Samnium.

Its site is occupied by the modern Venafro, a village on the railway from Isernia to Vairano, 25 km southwest of the former, 201 m above sea-level.

[3] Ancient authors tell us but little about it, except that it was one of those towns governed by a prefect sent yearly from Rome, and that in the Social War it was taken by the allies by treachery.

Its olive oil was the best in Italy, and Cato mentions its brickworks and iron manufactures.

The original line of the Via Latina probably ran through Venafrum, making a detour, which the later road seems to have avoided.