The Ventuari River is the largest tributary of the Orinoco in southern Venezuela.

[1] The Ventuari flows from south-central Venezuela in the Guiana Highlands southwest into the Orinoco River.

It is 520 km (320 mi) long and its major tributary is the Manapiare River.

The river drains the Guayanan Highlands moist forests ecoregion.

[2] The Ventuari River is the largest clearwater tributary of the Orinoco.