The Portuguesa River (Spanish: Río Portuguesa, also Río la Portuguesa, Río de la Portuguesa) is a river of Venezuela.

It is part of the Orinoco River basin, and is a tributary of the Apure River (which is, in turn, a tributary of the Orinoco).

Legend has it that the river's name originated from a woman from Portugal who drowned in its waters.

In turn, the river's name is the origin of the name of the Venezuelan state of Portuguesa.

This article related to a river in Venezuela is a stub.