[1] Verbenone can be readily prepared synthetically by the oxidation of the more common terpene α-pinene:[2] Verbenone can then be converted into chrysanthenone through a photochemical rearrangement reaction:[3] The southern pine beetle (Dendroctonus frontalis), a bark beetle, is a major threat to pine trees in the southeastern United States.

They then place verbenone formulations on nearby susceptible healthy trees to repel and confuse the beetles.

[5] Verbenone is recognized by the mountain pine beetle, Dendroctonus ponderosae Hopkins, a notable forest insect capable of causing extensive levels of tree mortality in western North America.

Verbenone is also used to manage redbay ambrosia beetle (Xyleborus glabratus) the vector of the fungus that causes laurel wilt.

A 9-month trial in forest demonstrated a reduction in the number of beetles landing on redbay and a reduction in redbay mortality [8] Because of its pleasant aroma, verbenone (or essential oils high in verbenone content) are used in perfumery, aromatherapy, herbal teas, spices, and herbal remedies.