[3] VT 105 begins at a fork from US 7 (Swanton Road) in the Franklin County city of St. Albans.

The route turns east and merges into Seymour Road, which changes names to Sheldon.

[4] At this junction, VT 105 turns further to the northeast, retaining the Sheldon Road moniker as it crosses through rural St. Albans.

The route runs southeast out of Sheldon Springs, paralleling the tracks, and crossing Missisquoi River.

Crossing through Sheldon Junction, the route makes a curve to the northeast again, paralleling the Missisquoi River.

[4] VT 105 soon crosses into Enosburg Falls runs southeast into the village, being main west–east road through the community.

Fast approaching the Canada–United States border, the route turns northeast and into a junction with VT 105A (Glen-Sutton Road).

Making a huge curve to the southeast, the route parallels the border, crossing into Orleans County.

The route enters the hamlet of Newport, where it is the main northwest–southeast street through the community as a two-lane residential road.

North of Walker Pond, the route bends northeast and turns east into the city of Newport.

[4] Now named Highland Avenue, VT 105 runs eastward along the hills around Newport, reaching a junction with US 5 (Pleasant Street).

On the other side of the lake, the route parallels the Clyde River, reaching a junction with the western terminus of VT 191.

After the junction with Western Avenue, the route continues along East Main, passing north of Clyde Pond.

The route bends southward past Charleston Pond, where VT 5A forks to the southwest.

Paralleling the Clyde River, reaching Pensioner Pond, which is surrounded by both routes on each shore, VT 105 turns further to the southeast, passing through the hamlet of East Charleston.

Now paralleling the Nulhegan River, VT 105 enters the town of Ferdinand, crossing through the hamlet of East Brighton.

Continuing along the railroad tracks, VT 105 makes a long bend southeast and turns northeast again up a mountainside.