Vermont Route 143 (VT 143) is a 5.75-mile-long (9.25 km) state highway within the town of Springfield in Windsor County, Vermont, United States.

The route heads eastward out of the town, and begins a windy journey, turning north, then east, then back to the north, and then to the northeast towards Interstate 91.

This intersection is Route 143's eastern terminus, just feet from the banks of the Connecticut River and the state border with New Hampshire.

This is an isolated area, however, and the nearest border crossings are nearly 5 miles (8.0 km) in each direction: Route 11 crosses the border to the south, southeast of Springfield, and Route 12 crosses the border to the north from Ascutney.

These two routes, the closest major roads (aside from US-5) accessible from Route 143's eastern end, also provide the closest access to I-91, at exit 7 in the south and exit 8 in the north.