The main campus of Vernon-Verona-Sherrill High School was built in 1954, and is centrally located between the towns of Vernon and Verona and the city of Sherrill at the intersection of New York State Route 31 and Beacon Light Road.

Facilities include a theater, two gymnasiums, fitness center, cafeteria, and a maple syrup factory operated by the Future Farmers of America (FFA) program.

Students can also take Advanced Placement courses in a number of subjects and receive vocational training at the local Madison-Oneida county BOCES.

Co-curricular activities and service groups include The Red Zone (school store), The Red Press (school newspaper), peer mediation, National Honor Society, Yearbook Club, Future Farmers of America, LEAD USA, Student Council, Boys’ State, Girls’ State, Global Nexus, student tutors, reading buddies, and Colgate Seminar.

Sports compete at the Class B, C and D levels in Section III of the New York State Public High School Athletic Association.