She also attended various courses organised by National School of Drama, Delhi and workshops conducted by noted theatre personality Satyadev Dubey.

[2] Deshpande received her first acting break for a cameo role as a receptionist in the multi-award-winning 2004 film Shwaas.

Deshpande's role was of a supportive wife who helped her husband in his journey towards making India's first full-length feature film Raja Harishchandra.

Based on the novel of same name by Anand Yadav, Dwarka's character was of a wife who dislikes her husband's involvement in Tamasha.

[5] In 2011, Deshpande portrayed another historic role of wife of one of the greatest Marathi singers and stage actors, Bal Gandharva.