He has voiced characters in over 100 anime and video game titles, including Dragon Ball Z, Bleach, Code Geass, Shin-chan, and Hell Girl.

Other animation roles include Broly from the Dragon Ball films, Tamaki Suoh in Ouran High School Host Club, Fai D. Flowright in Tsubasa: Reservoir Chronicle, Dark in D.N.Angel, Kurz Weber in the Full Metal Panic!

series, Zero and Ichiru Kiryu in the Vampire Knight series, Christopher Aonuma in Digimon Fusion, Nagato and Obito Uchiha in Naruto Shippuden, Kougaiji in Saiyuki, Ikkaku Madarame in Bleach, Rohan Kishibe in JoJo's Bizarre Adventure: Diamond Is Unbreakable, Hideki Kurohagi in Marvel Anime: Wolverine, Qrow Branwen in RWBY, and Matt Ishida in Digimon Adventure tri.

In early 2019, following sexual harassment allegations from the MeToo movement dating back to when his career began, Mignogna was dismissed from Sony Pictures and Rooster Teeth, but denied any accusations against himself.

[5] He graduated from Liberty University with a degree in television and film production,[6][7] and taught English and speech at Trinity Christian Academy in Jacksonville, Florida.

[9] Vic Mignogna has voiced characters in over 100 anime and video game titles, including Dragon Ball Z, Bleach, Code Geass, Shin-chan, and Hell Girl.

[10] While working in video production with John Gremillion in Houston, Mignogna got involved in voice acting at ADV Films.

[4][9] He debuted as Vega in the video game-based anime series Street Fighter II V.[11][4][12][13][14] Mignogna started attending anime conventions, where he contacted Funimation and landed the voice role of Broly in the Dragon Ball Z movies, as well as Dragon Ball Super: Broly.

[9] As a musician, he has released several albums, some of which feature English cover versions of anime songs from shows, including the Funimation dub of One Piece and the Dragon Ball series.

[1][39][40][41] Multiple accounts alleged that he kissed, groped, and made lewd or homophobic comments to fans without their consent, some of whom were underage.

[39][40][42] Voice actresses Monica Rial and Jamie Marchi tweeted their support for those speaking out, and alleged that he had also sexually harassed them.

[1][50] On February 20, Mignogna confirmed on Twitter that he was pursuing legal action,[51] and later filed a million-dollar lawsuit against Funimation, Rial, Marchi, and Ron Toye for defamation and tortious interference in the Tarrant County District Court.

[54] Rial, Marchi, and Toye then filed anti-SLAPP motions on July 19,[55] with ten affidavits, including ones from Kara Edwards and Michele Specht,[8][1] as well as several allegations that he had also made unwanted advances towards Mari Iijima.

[62] In February 2021, in response to the allegations, Mignogna announced outside of Funimation, that he will not reprise his role as Rohan Kishibe, a character from JoJo's Bizarre Adventure, in the anime adaptation of the spin-off of the Diamond Is Unbreakable arc, Thus Spoke Rohan Kishibe, and thanking his replacement Landon McDonald, wishing him the best.