He[a] is considered one of the most successful entertainers in Philippine show business,[4][5] noted for his stand-up routines, usage of observational comedy, situational irony and sarcasm in pertaining to Filipino culture and human sexuality.

He became more recognized in the talent search program It's Showtime (2009) and gained widespread popularity in his first lead role in the 2010 remake film Petrang Kabayo and staged his first major concert May Nag-Text.. 'Yung Totoo!

[23] His father, a native of Taysan, Batangas, and a barangay captain in Tondo, Manila, was murdered when he was young, prompting his mother, an Ilocana from San Juan, La Union, to leave her children to work abroad as a caregiver.

[24] Vice was able to sustain his studies due to a scholarship granted by an unknown Japanese woman who funded his education from third grade until second year college.

[30] In 1999, a talent scout and now a fellow television comedian and manager, Ogie Diaz, discovered Vice in one of his visits to the comedy bars.

With this career break through, Vice's life story of being bullied as a young, closeted homosexual has also been featured in the drama anthology, Maalaala Mo Kaya.

[44] The movie became the first local film to reach ₱300 million in ticket sales, and proved to be an even greater box office success than Petrang Kabayo.

[48] In 2013, he starred in another hit movie alongside Maricel Soriano called Girl, Boy, Bakla, Tomboy, an official entry of the 2013 Metro Manila Film Festival.

[61] In the same year, he became judge in the 5th and 6th seasons of Pilipinas Got Talent, along with his fellow celebrities, Angel Locsin and Robin Padilla and in Pinoy Boyband Superstar with Aga Muhlach, Yeng Constantino and 2NE1 member Sandara Park.

[62][63][64] In 2017, he starred in another Metro Manila Film Festival entry titled Gandarrapiddo: The Revenger Squad alongside Daniel Padilla and 2015 Miss Universe Pia Wurtzbach.

[77] The show made Vice Ganda the first Filipino to win "Best Lifestyle", "Entertainment Presenter/Host" in the fourth Asian Academy Creative Awards (AACA).

[79] After few months, with the easing of restrictions, Vice returned to live stage with his concert "Vax Ganda: A Dose Of Laughter" at Pechanga Resort & Casino in Temecula, California and in Mohegan Sun in Connecticut.

[84] Ganda also won "Best Variety Show Host" at the 2023 Platinum Stallion National Media Awards of Trinity University of Asia.

It features mostly pop and novelty songs, including his lead single "Palong Palo", written by Callalily frontman Kean Cipriano.

[90] Ganda's carrier single "Karakaraka" featuring Filipino rapper Smugglaz quickly reached the top spot of the most-downloaded songs in the online musical portal MyMusicStore on the first day of its release.

In 2014, Vice Ganda released his 3rd album, entitled #Trending, which featured the song "Boom Panes" and "Push Mo Yan Teh!".

In 2016, Vice released the sound track for his film The Super Parental Guardians, titled as "Ang Kulit", an original composition under Star Records.

[102] In line with the launch, a concert named "Ganda For All" was held at the Smart Araneta Coliseum with various performers including its first ever celebrity endorsers, Maymay Entrata and Kisses Delavin.

"[111] At Robredo's miting de avance (final rally before election day), he also endorsed Senator Kiko Pangilinan for vice president.

[112] In 2013, Vice Ganda auctioned off some of his clothing and performed for a fundraising comedy show and donated all proceeds to ABS-CBN's Sagip Kapamilya (Save a Family) relief operations for those affected by Super Typhoon Yolanda, one of the deadliest and most powerful tropical cyclones ever recorded.

[113][114][115][116] He also joined a charity basketball game organized by fellow celebrities and PBA players held at Ynares Sports Arena in Pasig City to raise funds for families affected particularly in the Visayas region.

[118][119][120] Apart from his extensive donation campaign for medical frontliners, Vice Ganda also provided financial assistance to more than 400 employees of his cosmetics company.

[118] Vice Ganda also launched his post-birthday donation drive for two barangays in Quezon City wherein he handed relief packs containing canned goods, rice, noodles, soaps, among others to 850 families in Brgy.

[122] Vice Ganda also partnered with Angel Locsin to provide beds in a temporary air-conditioned sleeping tents for medical staffs and other essential workers of Taguig City.

[129] In January 2022, he donated ₱500,000 to a 10-day benefit concert headed by Regine Velasquez in the "Tulung-Tulong sa Pag-ahon campaign" of ABS-CBN Foundation to aid further recovery of typhoon Odette-affected families.

[130] In March 2022, in a vlog uploaded in his YouTube account, Vice extended help to random strangers by paying for the medicines they bought in a pharmacy opposite AFP Medical Center in Quezon City.

[131] In April 2024, Ganda and fellow It's Showtime hosts donated their winnings from Family Feud to their chosen beneficiary, "PISTON," an association dedicated to jeepney drivers nationwide.

[132] Vice Ganda's use of sarcasm in his style of comedy is cited by various researchers as a major contributing factor to the modern Filipino humor.

[133] In a separate study by the Centro Escolar University and Western Mindanao State University about the pragmatics of Filipino humor, Vice Ganda's popularity in various entertainment mediums like television and the internet, as well as his use of irony and conversational witticisms greatly influenced the popular comedic strategies used by Filipinos in their day-to-day conversations, sometimes even to the point of being disrespectful towards the elderly among Vice Ganda's younger audience.

[134] The popularity of Vice Ganda, an openly gay individual, in the Philippines, a predominantly Roman Catholic nation, is seen by observers as vital in kickstarting discussions of LGBT people to the mainstream media.