The longest vice presidential tenure as caretaker in Argentine history took place between 1865 and 1868, while President Bartolomé Mitre was preoccupied with the Paraguayan War.

Seven Argentine vice presidents have succeeded to the presidency: Juan Esteban Pedernera (1861); Carlos Pellegrini (1890); José Evaristo Uriburu (1895); José Figueroa Alcorta (1906); Victorino de la Plaza (1914); Ramón Castillo (1942); and Isabel Perón (1974).

The Argentine Constitution does not provide for the replacement of a vice president should their tenure be ended for any reason, and their office was thus made vacant on seventeen occasions since 1861 (see list).

The current incumbent, Victoria Villarruel, took office on December 10, 2023.

The current Vice President of Argentina is Victoria Villarruel, of the Democratic Party (affiliated with La Libertad Avanza), who took office on December 10, 2023, after in the 2023 presidential elections the formula headed by Javier Milei won the contest in the second round with 55.65% of the votes.