He is a Distinguished Professor and Vice Chair of Basic Research at the Department of Pediatrics at the University of California, San Diego (UCSD) School of Medicine.
A native of Santa Barbara, California, Nizet received his undergraduate education at Reed College in Portland, Oregon, completed his MD degree at Stanford University School of Medicine, a Residency and Chief Residency in Pediatrics at Harvard University/Boston Children's Hospital, and fellowship in Pediatric Infectious Diseases at the University of Washington/Seattle Children's before joining the UCSD faculty in 1997.
Additional lines of translational research pursue therapeutic strategies for serious or antibiotic-resistant infections are pursued including neutralization of bacterial virulence phenotypes, pharmacologic augmentation of host phagocyte function, and repurposing of existing drugs for unexpected beneficial activities operating at the host-pathogen interface.
Nizet's other focus areas include cross-disciplinary research and educational program development, enhancing graduate and postdoctoral training in biological, medical and pharmaceutical sciences.
[citation needed] Nizet has authored over 560 peer-reviewed publications and has collaborated with several biotechnology interests in developing new antibiotic and immune-based therapies against drug-resistant pathogens.